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KMID : 0367320010120010071
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Journal of the Korean Academy of Child and Adolescent Psychiatry
2001 Volume.12 No. 1 p.71 ~ p.78
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PSYCHIATRIC CHARACTERISTICS OF CHILD PATIENTS WITH INVERSION OF CHROMOSOME 9 -A PRELIMINARY STUDY-
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Kim Jae-Won
Lee Jun-Young
Hwang Jun-Won
Hong Kang-E
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Abstract
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Objectives: Few studies have examined the psychiatric properties of child developmental problems associated with inversion of chromosome 9. The purpose of this study is to examine the psychiatric properties of child patients who have inversion of chromosome 9, focused on behavioral problems and child developmental problems like motor or language denelopmental delay, intellectual impairment, and growth retardation.
Method:
1) The authors examined the cases referred for cytogenetic examination from 1984 to 2000 at Seoul National University Hospital in Korea. The cases with the examination result of inversion of chromosoem 9 were collected and informations about the departments which referred and the main reasons for referral were also checked.
2) 12 child subjects with inversion of chromosome 9 and their parents underwent psychiatric interview and parent questionnaire (child and adolescent past history questionnare, CBCL). 45 normal students whose sex and age were matched to patients were selected as a control group.
Results:
1) There were 165 cases of inversion of chromosome 9. The major departments which referred were Obstetrics and Gynecology(47.3%), Pediatrics(23.6%) and Child and Adolescent Psychiatry (17.0%). The major reasons for referral from the pediatrics and the Child and Adolescent Psychiatry department (67 cases total) were intellectual impairment (35.8%), language or motor developmental delay(31.3%), suspected Fragile X syndrome(23.9%), and growth retardation(20.9%).
2) Compared to normal control group, the rate to be included in the clinical range with regard to the social problems profile was higher in patient group according to the CBCL results. The patient group had language and motor developmental delay.
Conclusion: There is a possibility of chromosome 9 to be associated with child developmental problems or behavioral problems. This study is the first approach to evaluate the developmental aspects associated with inversion of chromosome 9.
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KEYWORD
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Inversion of chromosome 9, Development, Behavioral problems,
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